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M9490125.TXT
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1994-09-03
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Document 0125
DOCN M9490125
TI [Effect of synthetic fragments of immunodominant regions of HIV viral
proteins on the oxygen metabolism of human neutrophils]
DT 9411
AU Zemskov VM; Drukh VM; Subbotin SM; Andreev SM; Sidorova MV; Vafina MG;
Tsvetkov DE; Vorob'ev AA
SO Biull Eksp Biol Med. 1993 Feb;115(2):185-7. Unique Identifier : AIDSLINE
MED/94318879
AB Influence of synthetic peptides identical to fragments of natural human
immunodeficiency virus (HIV) glycoproteins gp 120 and gp 41, on
luminol-enhanced chemiluminescence (CL) of human neutrophils has been
studied. It was established that some of peptide analogs of gp 120 and
gp 41 immunodominant regions are able to suppress spontaneous CL: but
when being used with dimethylsulfoxide they dramatically stimulate it
and deteriorate opsonized zymosan-induced CL. Conclusions about the
necessity of possible side effects considering during use of peptide
vaccines against HIV have been made. It is also possible to explain some
neutrophil dysfunction in HIV infected subjects as the result of HIV
glycoproteins direct influence on this cells.
DE Acquired Immunodeficiency Syndrome/METABOLISM/PATHOLOGY
Chemiluminescence Dimethyl Sulfoxide/PHARMACOLOGY English Abstract
Human HIV Envelope Protein gp120/*CHEMISTRY HIV Envelope Protein
gp41/*CHEMISTRY Immunodominant Epitopes/*IMMUNOLOGY Neutrophils/DRUG
EFFECTS/IMMUNOLOGY/*METABOLISM Oxygen/*METABOLISM Respiratory Burst
Zymosan/PHARMACOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).